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Apredica: Early ADME Tox / ADMET Contract Research

Careers at Apredica

Apredica is committed to building and maintaining a culture that values our people as our most important assets and as partners in the company's success. Realizing that the interests of the company and its people go hand in hand, we are committed to attracting the best talent available.

We believe that our competitive edge lies in the quality of the team we assemble to serve our clients. Responsibility and authority within Apredica is delegated to all our employees, each of whom is encouraged to make decisions and to take action to realize their own potential in the process of fulfilling serving our clients.

Apredica is accessible by public transportation via the 70/70A bus line running between Central Square Cambridge, Watertown Square, and Waltham.

Apredica is an equal opportunity employer. Qualified candidates for available positions should email their résumés to careers@apredica.com.


Open Positions

Senior Scientist, Study manager

Job Purpose

This is an opportunity for an experienced pharmaceutical industry scientist to aid in the management of client studies, as well as develop, validate and assist in introducing new ADMET technologies to market.

Apredica, a wholly owned subsidiary of Cyprotex, is seeking a hands-on drug discovery and development toxicologist to:

  • provide day-to-day support and management of client studies:
    • Manage studies in the lab
    • QC, complete, write, present and explain reports to clients
    • Provide consulting to clients on drug discovery programs in relation to de-risking their programs and designing appropriate ADMET strategies.
  • Provide tangible contributions to the implementation and development of new and existing assays
  • Provide support for business development in doing technical presentations to current and prospective clients
  • Actively contribute in the drug discovery and development process of the company's clients from early-stage discovery through lead selection

You will work in a collaborative international team environment with other colleagues at Apredica (US) and Cyprotex (UK) involved in ADME Tox, drug metabolism, and preclinical development. You will be involved in technology coordination and transfer between Apredica's US site and Cyprotex's UK site. The role involves some occasional travel to client site, industry events and our UK laboratory.

The position can start as a senior scientist, with progression to study manager. A candidate with good management skills and sufficient industry experience will serve as a project manager and staff supervisor. Candidates with good presentation and superior scientific skills may represent the company at national and international meetings for preclinical safety issues, and participate in external industry initiatives to improve drug safety assesment paradigms.

Requirements

  • Experience running drug discovery programs in pharmaceutical companies
  • Management experience
  • Ability to contribute towards the creation of white papers and marketing materials for the company's new assays
  • Ability to develop strategies and plans for achieving project goals
  • Ability to work in an industrial, fast-paced, team environment
  • Excellent written and verbal communication skills
  • The ability to work independently.

Basic Qualificaiton

  • Results-oriented Ph.D.-level scientist with a biological science background and experience in drug discovery
  • A minimum of 6 years of pharmaceutical industry experience.

Preferred Qualifications

  • Experience with outsourcing, especially discovery work
  • The ability to build productive, cross-functional collaborations both internally and externally.

Principals only. Relocation assistance not provided.

To apply, email your résumé to careers@apredica.com

Scientist, Cell Culture and Imaging

This is an opportunity for a biologist with 2-4 years of experience in the pharmaceutical industry to assist in ADME and in vitro toxicity assays at a fast-paced, international company, the world leader in ADMET innovation.

Apredica, a subsidiary of Cyprotex, is seeking a hands-on, highly motivated scientist to apply fundamental cell biology, biochemistry, and analytical techniques to conduct routine ADME and in vitro toxicity assays. The successful candidate will actively participate in experiment design, performance and troubleshooting, as well as data analysis and interpretation. The ideal candidate will be independent, self-motivated, collaborative, and able to multitask effectively. You will work in a collaborative, international team environment with other colleagues at Apredica (US) and Cyprotex (UK).

Requirements

  • Experience working in drug discovery programs in pharmaceutical companies or CROs
  • Cell culture skills
  • Excellent written and verbal communication skills
  • The ability to work independently.

Basic Qualifications

  • Results-oriented B.S./M.S.-level scientist with a biological science background with experience in drug discovery
  • A minimum of 2 years of pharmaceutical industry experience.

Preferred Qualifications

  • Cell imaging, especially High Content Screening
  • Use of analytical equipment such as HPLC and LC/MS/MS
  • Experience with laboratory automation equipment.

Principals only. Relocation assistance not provided.

To apply, email your résumé to careers@apredica.com.

Scientist, In Vitro Toxicology

This is an opportunity for a toxicologist to make an impact on early safety assessment by incorporating some common and proprietary in vitro toxicology tools into the drug development process, and by developing and validating new tools.

Apredica, a wholly owned subsidiary of Cyprotex, is seeking a hands-on drug discovery and development toxicologist to:

  • provide toxicology leadership to the company
  • actively contribute in the drug discovery and development process of the company's clients from early-stage discovery through lead selection
  • provide guidance on animal toxicology and clinical development

You will work in a collaborative international team environment with other colleagues at Apredica and Cyprotex involved in ADME, drug metabolism, and preclinical development); and you will contribute to the early safety assessment of small-molecule and biologic therapeutics.

You will design, implement, manage, and analyze data from a variety of in vitro assays currently developed and validated at Apredica, and make recommendations for drug development candidates.

You will be involved in technology coordination and transfer between Apredica's US site and Cyprotex's UK site that will require working with an international multidisciplinary team of scientists and occasional travel to the UK.

Opportunities exist to serve as a lead on toxicology on multiple studies, and to supervise staff for the implementation and oversight of studies supporting nonclinical development of our clients' portfolios. You may represent the company at national and international meetings for nonclinical safety issues, and participate in external industry initiatives to improve drug safety assessment paradigms.

Requirements

  • Occasional travel to conferences to present results in poster and talk formats.
  • Ability to write articles for publication in peer-reviewed journals is required.
  • Ability to contribute towards the creation of white papers and marketing materials for the company's toxicology offering.
  • Experience in resolving preclinical safety issues through the establishment of novel protocols and designing in vitro proof-of-principle assays, to solve experimental questions
  • Ability to develop strategies and plans for achieving project goals.
  • Ability to work in an industrial, fast-paced, team environment.

Basic Qualifications

  • Results-oriented Ph.D.-level scientist with a biological science background with emphasis in toxicology, or a D.V.M. with toxicology or pathology expertise.
  • A minimum of 2 years of pharmaceutical industry experience in nonclinical safety assessment, in vivo-in vitro correlations, in vitro assessment of mechanisms of toxicity, and nonclinical drug development.
  • Experience in the preparation, writing and review of regulatory documents (both IND and NDA/BLA).

Preferred Qualifications

  • Post-doctoral research experience in a toxicology specialty area.
  • Board certification in toxicology or pathology.
  • Experience in critically evaluating and interpreting the results of scientific experiments.
  • Prior experience with US and international regulatory agency interactions.
  • Prior contributions to appropriate sections of INDs, BLAs, NDAs, and other regulatory documents.
  • A working understanding of cutting-edge science and technology (high-content screening in particular) being used to enhance investigation of drug development safety issues.
  • Excellent written and verbal communication skills.
  • The ability to work independently.
  • The ability to build productive cross-functional collaborations both internally and externally.

Principals only. Relocation assistance not provided.

To apply, email your résumé to careers@apredica.com.