DMPK Services

Drug Metabolism Pharmacokinetic (PK) Studies

Apredica offers a full range of in vivo and in vitro pharmacokinetic studies of drugs and drug metabolites in rodents (rats and mice), including:

In Vivo DMPK Services

• All routes of administration (IP, IV, PO, SC etc.)
• Pre-formulation development
• Bioavailability
• Blood-brain barrier permeability
• Single, multiple, and cassette dosing
• Metabolite identification

In Vitro DMPK Services

• Species comparison of metabolism in microsomes
• Species comparison of metabolism in hepatocytes
• Metabolic CYP pathway identification
• Metabolite profiling and structural elucidation
• Cytochrome P-450 inhibition (IC50 and Ki) in human liver microsomes
• Plasma protein binding and blood cell partitioning
• Plasma stability

Apredica's scientists have many years of pharmaceutical drug experience and can guide you through the appropriate ADME, predictive toxicology and PK studies. Apredica's state-of-the-art bioanalytical services and fast turn around times will help you make your go/no-go decisions faster while reducing your total clinical and preclinical study costs.

Contact us to learn more about Apredica's DMPK services.