Events and Speaking Engagements
SOT Annual Meeting & ToxExpo
Organization: Society of Toxicology
Location: Exhibit Hall E, Salt Palace Convention Center, Salt Lake City, UT
Date: 7-11 March 2010
Poster: A Sensitive HCS Assay to Evaluate Linezolid Toxicity, Using Sub-Lethal Cytotoxic Measurements in HepG2 Cells
Presenter: Katya Tsaioun, Ph.D., Apredica
SOT Annual Meeting & ToxExpo - Exhibitor-Hosted Sessions
Organization: Society of Toxicology
Location: Room 155 B, Exhibit Hall E, Salt Palace Convention Center, Salt Lake City, UT
Date: 10 March 2010, 12:15 PM – 1:15 PM
Topic: Mechanisms of Toxicity and Prediction of Whole-Organ Toxicity: In Vitro Assays and Their Validation. What Can We Predict Early On to Avoid Costly Mistakes Later?
Presenter: Katya Tsaioun, Ph.D., Apredica
North of Boston Business Plan Competition
Organization: Enterprise Center at Salem State College
Location: Recital Hall, Salem State College
Date: 3:00-6:00 pm, 16 April 2010
Topic: Contest Final
Judge: Doug Bates, Apredica
High Throughput Screening
Organization: SMi Group
Location: Crowne Plaza Hotel - St James, London, United Kingdom
Date: 26-27 April 2010
Topic: HCS and Multi-Parameter Readouts: De-Risking Drug Discovery Programs
Speaker: Katya Tsaioun, Ph.D., Apredica
ADMET
Organization: SMi Group
Location: Crowne Plaza Hotel - St James, London, United Kingdom
Date: 7-8 July 2010
Topic: Mechanisms of Human (Hepato)Toxicity
Speaker: Katya Tsaioun, Ph.D., Apredica
Past Events
Screening Europe
Organization: Select Biosciences
Location: Barcelona, Spain
Date: 11-12 February 2010
Topic: HCS for Prediction of Mechanisms of Drug Toxicities: Prediction of Organ Toxicity or Specific Mechanisms?
Speaker: Katya Tsaioun, Ph.D., Apredica
Predictive Human Toxicity and ADME/Tox Studies
Organization: Mondial Research Group
Location: Brussels, Belgium
Date: 26-27 January 2010
Topic: Novel In Vitro System for the Toxicological Evaluation of Genotoxic Compounds
Speaker: Katya Tsaioun, Ph.D., Apredica
Growing the Great Idea
Organization: 128 Venture North
Location: Enterprise Center, Salem, MA
Date: 22 January 2010
Speaker: Doug Bates, M.S., M.B.A., Chief Business Officer, Apredica
Business Strategies and Models
Organization: Harvard-MIT Health Sciences & Technology
Location: Harvard Medical School, Boston, MA
Date: 11 January 2010
Speaker: Doug Bates, M.S., M.B.A., Chief Business Officer, Apredica
PPTOXII: Role of Environmental Stressors in the Developmental Origins of Disease
Organization: Society of Toxicology
Location: Miami Beach, Florida
Date: 7-10 December 2009
Topic: In Vitro Models of Mechanisms of Human Toxicity: Validation and Application for Developmental Toxicology
Presenter: Katya Tsaioun, Ph.D., Apredica
Cell Based Assays
Organization: SMi Conferences
Location: Crowne Plaza Hotel - St James, London, London, UK
Date: 18-19 November 2009
Topic: Cell-Based Assays that Detect Mechanisims of Human Hepatatotoxicity
Speaker: Katya Tsaioun, Ph.D., Apredica
How to Solve the Problem of Access to Human Tissues for Medical Research
Organization: Safer Medicines Trust
Location: House of Lords, Parliament, London, UK
Date: 20 October 2009
Topic: De-Risking Drug Discovery with ADDME - Avoiding Drug Development Mistakes Early. Alternatives to Laboratory Animals.
Speaker: Katya Tsaioun, Ph.D., Apredica
16th North American Regional ISSX Meeting
Organization: International Society for the Study of Xenobiotics
Location: Baltimore Marriott Waterfront Hotel, Baltimore, MD
Date: 18-22 October 2008
Poster: Simultaneous Determination of Cyp450 Induction and Metabolism in Metabolically Competent Human Hepatocyte Cell Line HepaRG
Participants: Robert R. Annand, Ph.D.; Mary Jacewicz, Ph.D.; Katya Tsaioun, Ph.D., Apredica
Request poster
Poster: Quantity Production of Metabolites Using HepaRG Human Hepatic Cells
Participants: Robert R. Annand, Ph.D.; Mary Jacewicz, Ph.D.; Katya Tsaioun, Ph.D., Apredica
Request poster
Innovation in Life Science & Healthcare Research & Product Development
Organization: DouglasConnect
Location: Bryn Mawr, Philadelphia, PA
Date: 13-16 October 2009
Topic: In vitro Models that Predict Major Known Mechanisms of Human Toxicity. Validation, Case Studies and Path Forward
Speaker: Katya Tsaioun, Ph.D., Apredica
ADDME: Avoiding Drug Develoment Mistakes Early
Organization: Parc Científic de Barcelona
Location: Barcelona Science Park, Barcelona, Spain
Date: 27 September 2009
Program: ADDME: Avoiding Drug Develoment Mistakes Early
Speaker: Katya Tsaioun, Ph.D., Apredica
Approaches to Assessing Drug Safety in the Discovery Phase
Organization: The Society for Medicines Research
Location: National Heart & Lung Institute, Kensington, London, UK
Date: 24 September 2009
Program: Exhibition area
Participants: Katya Tsaioun, Ph.D., Apredica
2nd Alzeheimer's Disease Translational Research Investigators' Meeting
Organization: National Institute on Aging
Location: Bethesda, MD
Date: 10-11 September 2009
Topic: ADDME: Avoiding Drug Development Mistakes Early - Academic perspective
Speaker: Katya Tsaioun, Ph.D., Apredica
Annual Conference on Small Molecule Science (CoSMoS)
Organization: Society for Small Molecule Science
Location: Boston, MA
Date: 3-5 August 2009
Topic: Outsourcing Hit-to-Lead and Lead Optimization Work: When It Makes Sense to Bring it In-House - Economics and Case Studies
Speaker: Katya Tsaioun, Ph.D., Apredica
Pharma Outsourcing
Organization: Select Biosciences
Location: London, UK
Date: 25 June 2009
Topic: New Approaches for De-Risking and Accelerating Your Pipeline
Speaker: Katya Tsaioun, Ph.D., Apredica
Drug Discovery: Easing the Chemistry Bottleneck
Organization: Opal Events
Location: Pennsylvania Convention Center, Philadelphia, PA
Date: 8-9 June 2009
Topic: Teaming up to Tame the Bottleneck: Industrial-Academic Interactions
Speaker: Katya Tsaioun, Ph.D., Apredica
Massachusetts Life Sciences Innovation Day 2009
Organization: Massachusetts Technology Transfer Center
Location: Sheraton Boston Hotel, Boston, MA
Date: 3 June 2009 8:00 a.m. - 6:00 p.m.
Program: Showcased laboratory
Participants: Katya Tsaioun, Ph.D., Apredica
Applied Pharmaceutical Toxicology 2009
Organization: Applied Pharmaceutical Toxicology
Location: Harvard Medical Conference Center, Boston, MA
Date: 11-13 May 2009
Topic: Cell Models for Prediction of Human Toxicity. Validation and Case Studies
Speaker: Katya Tsaioun, Ph.D., Apredica
PCI Synthesis Open House
Organization: PCI Synthesis
Location: 9 Opportunity Way, Newburyport MA
Date: 8 May 2009 9:00-11:00am
Topic: ADDME - Avoiding Drug Development Mistakes Early
Speaker: Katya Tsaioun, Ph.D., Apredica
2009 Massachusetts State High School Science & Engineering Fair
Organization: Massachusetts State Science & Engineering Fair
Location: Kresge Auditorium, Building W16, MIT, Cambridge, MA
Date: 1 May 2009
Judge: Katya Tsaioun, Ph.D., Apredica
Society of Toxicology 2009 Annual Meeting
Organization: Society of Toxicology
Location: Baltimore Convention Center, Baltimore, MD
Date: 15-19 March 2009
Program: Poster Presentation
Participants: Mary Jacewicz, Ph.D.; Robert Annand, Ph.D.; Jonathan Gilbert; Katya Tsaioun, Ph.D., Apredica
Request poster
First Friday Bioscience Seminar
Organization: North Shore Technology Council
Location: 100 Cummings Center, Suite 339-F, Beverly, MA 01915
Date: 6 March 2009 12:30 PM - 02:00 PM
Topic: Drugs, Toxicity and Triage - new developments in the science of ADME-Tox testing for screening candidate drugs
Speaker: Katya Tsaioun, Ph.D., Apredica
ADMET Europe
Organization: Select Biosciences
Location: Hotel Berlin, Lützowplatz 17 10785, Berlin, Germany
Date: 23-25 February 2009
Topic: Reactive Intermediate Screen for Early Identification of Idiosyncratic Drug Reactions
Speaker: Katya Tsaioun, Ph.D., Apredica
3rd Drug Discovery for Neurodegeneration Conference
Organization: Alzheimer's Drug Discovery Foundation
Location: Park Hyatt, Washington DC
Date: 2-3 February 2009
Topic: ADDME - Avoiding Drug Development Mistakes Early
Speaker: Katya Tsaioun, Ph.D., Apredica
Predictive Human Toxicity and ADME/Tox Studies
Organization: Mondial Research Group
Location: Brussels, Belgium
Date: 22-23 January 2009
Topic: Reducing the Cost of Drug Development using ADME Studies: Recent FDA Guidelines and Case Studies
Speaker: Katya Tsaioun, Ph.D., Apredica
Frontiers in Brain Diseases: From Bench to Bedside
Organization: Universidad de Concepción
Location: Concepción, Chile
Date: 12-16 January 2009
Topic: Specific Challenges of Translating CNS Discoveries into Medicines: Progress in the Last 20 Years
Speaker: Katya Tsaioun, Ph.D., Apredica
Balancing Professional and Personal Life - A Friedman School Alumni Career Panel
Organization: Tufts Friedman School Alumni Association
Location: Tufts Friedman School, 150 Harrison Avenue, Room 155, Boston, MA 02111
Date: 2 December 2008 5:15PM - 7:00PM ET
Moderator: Katya Tsaioun, Ph.D., Apredica
Speed and Safety in Drug Discovery
Location: The Royal Society, 6-9 Carlton House Terrace, London, UK
Date: 26 November 2008
Topic: ADDMEsm Avoiding Drug Development Mistakes Early
Speaker: Katya Tsaioun, Ph.D., Apredica
See recorded presentation. See recorded conference.
AAPS Annual Meeting and Exposition
Organization: American Association of Pharmaceutical Scientists
Location: Atlanta, GA
Date: 16-20 November 2008
Program: Exhibition hall
Contribution of Transporters to Permeability Across Cell Monolayers. Comparison of Three Models
Organization: American Association of Pharmaceutical Scientists
Location: Atlanta, GA
Date: 18 November 2008, 8:00 AM - 12:00 PM
Program: Poster
Participants: Mary Jacewicz, Ph.D., Apredica; Robert Annand, Ph.D., Apredica; Jonathan Gilbert, Apredica; Anne-Cécile Guyot, Commissariat ŕ l'Énergie Atomique; Aloďse Mabondzo, Commissariat ŕ l'Énergie Atomique
Request poster
Mammalian Cell Mitochondrial Toxicity Screen
Organization: American Association of Pharmaceutical Scientists
Location: Atlanta, GA
Date: 19 November 2008, 8:00 AM - 12:00 PM
Program: Poster
Participants: Mary Jacewicz, Ph.D., Apredica; Robert Annand, Ph.D., Apredica; Jonathan Gilbert, Apredica
Request poster
15th North American Regional ISSX Meeting
Organization: International Society for the Study of Xenobiotics
Location: Town and Country Resort & Convention Center, San Diego, CA
Date: 12-16 October 2008
Poster: Role of Specific and Non-Specific Inhibitors in Determining the Mechanism of Intestinal Drug Transport
Presenter: Katya Tsaioun, Ph.D., Apredica
Request poster
GBMSDG Vendor Night and Dinner Meeting
Organization: Greater Boston Mass Spectometry Discussion Group
Location: Hyatt Regency Cambridge, 575 Memorial Drive, Cambridge, MA
Date: 16 October 2008
Program: Exhibition hall
Participants: Robert Annand, Ph.D., Apredica
Intellectual Property Career Panel
Organization: IPconnectEd, Boston University School of Management
Location: Boston University, Boston, MA
Date: 9 October 2008
Program: Career panel
Participants: Katya Tsaioun, Ph.D., Apredica
9th International Conference on Alzheimer’s Disease Drug Discovery
Organization: Alzheimer's Drug Discovery Foundation
Location: New York, NY
Date: 6-7 October 2008
Program: Exhibition hall
Participants: Katya Tsaioun, Ph.D., Apredica
Drug Delivery 2008
Organization: Pharmaceutical Education Associates
Location: San Diego, CA
Date: 28-30 July 2008
Topic: Absorption and Toxicity in Intranasal and Lung Delivery
Speaker: Katya Tsaioun, Ph.D., Apredica
SMi’s 3rd Annual ADMET Conference
Organization: SMi Publishing
Location: The Hatton, at etc. venues, London, UK
Date: 2 & 3 July 2008
Topic: Combining In Vitro and In Silico Methods to Avoid Drug Development Mistakes Early
Speaker: Katya Tsaioun, Ph.D., Apredica; Pranas Japartas, Pharma Algorithms
Avoiding Hepatotoxic Surprises – An Update on Predictive Tools
Location: 500 Tech Square, Main St, Cambridge, MA
Date: 8:30 – 11:30am. 18 April 2008
Topic: ADDMEsm Avoiding Drug Development Mistakes Early -- Approaching Early Toxicity Assessment as a Business Decision
Speaker: Katya Tsaioun, Ph.D., Apredica
Breaking New Ground with Marketing
Location: Odeum Room, Campus Center, Worcester Polytechnic Institute, Worcester, MA
Date: 5:30 - 9:00pm. 8 April 2008
Topic: How to Market to Pharma Companies
Speaker: Katya Tsaioun, Ph.D., Apredica
Preclinical Trials: Strategies to Increase Your Chances of Success in Drug Development
Organization: BIOQuébec
Location: Montreal, Québec
Date: 27 March 2008
Topic: Lead Optimization – ADDMEsm: Avoiding Drug Development Mistakes Early
Speaker: Katya Tsaioun, Ph.D., Apredica
Predictive Human Toxicity and ADME/Tox Studies
Organization: Mondial Research Group
Location: Brussels, Belgium
Date: 24-25 January 2008
Topic: HERG-450: Combining Assays for Safety Assessment of Drug Candidates
Speaker: Katya Tsaioun, Ph.D., Apredica
"Funding Your Company: How to Finance Your Idea"
Organization: Women Entrepreneurs in Science and Technology
Location: Broad Institute, Cambridge, MA
Date: 29 November 2007, 6:00 pm to 9:00 pm.
Participants: Katya Tsaioun, Ph.D., Apredica; Joanna Horobin, M.D., Syndax Pharmaceuticals;
Ania Knap, Ph.D., MaxThera.
"Modern Tools in Drug Discovery and Later-Stage Development ADME-Tox Profiling"
Organization: Massachusetts Biotechnology Council
Location: MBC Office, One Cambridge Center, 9th Floor, Cambridge, MA
Date: 29 November 2007, 8:00 am to 10:00 am.
Participants: Katya Tsaioun, Ph.D., Apredica; Alex Avdeef, Ph.D., pION.
AAPS Annual Meeting and Exposition
Organization: American Association of Pharmaceutical Scientists
Location: San Diego, CA
Date: 11-15 November 2007
Program: Exhibition hall, booth #3532
IBC's Drug Discovery & Development of Innovative Therapeutics Conference
Location: Boston, MA
Date: 6-9 August 2007
Program: Exhibition hall
Seminar: Early Cardiac Toxicity Screening
Location: Cambridge, MA
British Consulate-General
One Memorial Drive, Suite 1500, Cambridge, MA 02142
Directions & Parking Map
Date: 7 June 2007, 8:00 am to 10:00 am
Registration and breakfast: 8:00 - 8:30 am
Seminar: 8:30 - 9:30 am
Discussion and networking: 9:30 - 10:00 am
Program: Drug-Drug Interaction and Cardiac Toxicity
Speakers: Arthur "Buzz" Brown, ChanTest; Katya Tsaioun, Ph.D., Apredica
Safety assessment prior to human clinical trials has become the norm in drug development.
It is crucial for reducing attrition in phase 2 and later development, where 75% of failures is
now due to safety and metabolism issues. To address this hurdle, the drug discovery and development
process is undergoing a paradigm shift. Discovery and development teams are functionally merging
so that safety issues are investigated much earlier than ever before.
The most common safety issues are associated with CYP450 and ion channels. CYP450 inhibition
can exacerbate interaction with ion channels. A prominent recent example of the consequences of
failure to investigate cardiac risk and CYP-3A4 inhibition is the withdrawal of Terfenadine from the market.
This seminar will feature:
- How cardiac safety and other ADME and toxicity issues can be assessed early, quickly, and economically.
- Case studies of drugs withdrawn from the market due to cardiac safety.
- How to use hERG data.
- Literature review on the correlation of human in vivo QT prolongation with available in vitro tests.
- Strategies and techniques for early assessment of cardiac risk.
- Which therapeutic areas and types of drug-discovery programs should be most concerned about cardiac safety.
- Ask the experts your questions about how to address cardiac safety issues in your programs.
Speakers:
Arthur Brown, M.D., ChanTest
Dr. Arthur M. "Buzz" Brown is the founder and CEO of ChanTest, a drug safety testing company specializing in ion channels.
He has more than 30 years of experience in ion channel biophysics. His research delineated the pores of voltage-gated
and inwardly rectifying potassium channels. At present, his research is on ion channel trafficking with special
emphasis on the hERG channel. He holds seven patents concerning ion channels and prevention and treatment of cardiac arrhythmias.
He is Adjunct Professor of Physiology and Biophysics, School of Medicine, Case Western Reserve University.
Dr. Brown has organized two academic departments at the University of Texas Medical Branch and Baylor College of
Medicine and one research institute, the Rammelkamp Center for Education and Research, MetroHealth Campus, Case Western Reserve University.
Katya Tsaioun, Ph.D., Apredica
Bio 2007
Location: MBC Office, One Cambridge Center, 9th Floor, Cambridge, MA
Date: 6-9 May 2007
Program: Exhibition hall - Emerging Companies Pavilion
"Managing Virtual Teams" -- Massachusetts Biotechnology Council
Location: MBC Office, One Cambridge Center, 9th Floor, Cambridge, MA
Date: 19 April 2007
Program: Case study of a collaborative relationship between a small drug-discovery company and contract research teams
Speaker: Katya Tsaioun, Ph.D., Apredica
Y50K Biotechnology Entrepreneurial Competition
Location: New Haven, CT
Date: 14 April 2007
Program: Final judging for the Y50K biotechnology business plan competition
Judge: Katya Tsaioun, Ph.D., Apredica, biotech judge
From Discovery to IND
Location: Baltimore, MD
Date: 13-14 March 2007
Topic: A Surer Path to IND: Early ADME-Tox Models for Reducing Downstream Risk of Drug Development
Speakers: Katya Tsaioun, Ph.D., Apredica; Ania Knap, Ph.D., MaxThera
Predictive Human Toxicity and ADME/Tox Studies
Location: Brussels, Belgium
Date: 25-26 January 2007
Topic: Early ADME-Tox Models for Reducing Downstream Risk of Drug Development and Increasing Productivity of Drug Discovery Organizations
Speaker: Katya Tsaioun, Ph.D., Apredica
|
