Mitochondrial Toxicity Screen

Apredica provides fast turnaround for drug-discovery toxicity studies. Contact us to learn more our toxicity testing services.

Many of the drugs removed from the market have been found to be mitochondrial toxicants. The cytotoxicity of drug candidates is frequently determined using cultured cell lines, which may not be sensitive to mitochondrial toxicants. Apredica grows cells in medium that is specially formulated to optimize sensitivity to mitochondrial toxicants (MITO+) and in medium in which the cells are resistant (MITO-) to mitochondrial toxicants. Cytotoxicity of compounds is assessed by titration with both cell lines. MITO+ cells are more sensitive to mitochondrial toxicants (Toxicant) than MITO- cells; there is no difference in sensitivity to non-mitochondrial toxicants (Non-Toxicant).

This assays allows for early detection of potential mitochondrial toxicants before they lead to development problems. Contact us to learn more.