Reactive Metabolite Toxicity Screen

Apredica provides fast turnaround for drug-discovery toxicity studies. Contact us to learn more our toxicity testing services.

Idiosyncratic Drug Reactions (IDRs) are a major reason for withdrawal of drugs from the market. While determining the underlying causes of IDRs is an active area of investigation, formation of reactive metabolites is hypothesized to play an important role in the development of unexpected toxicities of a number of compounds.

Apredica has developed an assay that looks for the formation of reactive metabolites, and which can be employed early in the discovery process, before the go/no-go decision about clinical candidates is finalized. Using our advanced LC/MS/MS techniques, adducts formed by reactive intermediates in metabolic assays can be detected and identified. Catching these intermediates early allows drug discovery organizations to reduce the potential risks for development of IDRs later in the drug-development process.

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