Toxicity Testing Services
Apredica provides fast turnaround for a wide variety of toxicology research for
drug-discovery programs, including both in vitro and in vivo toxicology research,
and product safety testing for REACH compliance.
Contact us to learn more our toxicity testing services.
Predictive Toxicology Services
Apredica provides a suite of predictive in vitro toxicology services
in screening, primary profiling, and full profiling modes. We offer in vitro cytotoxicity testing of test articles in HepG2,
NIH3T3, or HaCaT cells by Neutral Red or MTT assays, as well as
High-Content Imaging.
We also provide the following specialized toxicity tests, and we routinely develop
customized tests for clients' specialized needs. Please inquire
about custom cell lines or other in vitro toxicity assays.
Toxicology Screening
3 concentrations each unless indicated. Requires 12 compounds or more.
- Mammalian Cytotoxicity HepG2, TK6
- Mitochondrial toxicity
- Phospholipidosis
- hERG (2 concentrations)
- Reactive Metabolites
- 6 major Cyp450 (pooled LC/MS2 concentrations)
- P-gp (CaCO-2 cell functional assay)
- Genotoxicity - GreenScreen HC
- Hemolysis
- Phototoxicity
Primary Toxicology Profile
9 concentrations each unless indicated.
- Mammalian Cytotoxicity HepG2, TK6
- Mitochondrial toxicity
- Phospholipidosis
- hERG (6 conc in duplicate)
- Reactive Metabolites
- Genotoxicity - GreenScreen and GreenScreen + S9
Full Toxicology Profile
9 concentrations each unless indicated.
- Mammalian Cytotoxicity HepG2 & TK6
- Mitochondrial toxicity
- Phospholipidosis
- hERG (6 conc in duplicate)
- Reactive Metabolites
- 5 major Cyp450 (2 concentrations screen + 2 IC50 determinations)
- P-gp (bi-directional + verapamil)
- Genotoxicity - GreenScreen HC + S9
- Hemolysis
- Phototoxicity
In Vivo Preclinical Toxicology
Determining the liabilities and potential for gross toxicity of NCEs early in the
preclinical process can save large amounts of time and money on GLP toxicology studies.
Apredica offers customized preclinical discovery-phase rodent toxicity studies in
both single-escalating and multiple-dosing regiments with rapid turnaround. Please inquire about your preclinical animal tox needs.
Please contact us about these or any cutomized tests that you may need for your drug-discovery program.
Predictive Toxicology
In recent years tremendous advances have been made in predictive toxicology,
allowing early, cost-effective prediction of human toxicity. Identifying compound
toxicity as early as possible can better direct your chemistry efforts, and ultimately
support improved candidate selection and clinical trial success.
The Safer Medicines Trust has developed a well-done film on this subject.
The trailer is below, or see the full film.
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