Toxicity Testing Services

Hepatotoxicity and cardiotoxicity continue to be responsible for drug attrition at all the stages of the drug development process¹. Once a therapeutic has reached the market, these toxicities are the cause of black-box warnings, lawsuits, and withdrawal of approved drugs from the market.^1,2 Consequently, identifying potential toxicities as early as possible can reduce the possibility of observing late stage failures, improve patient outcomes and save both time and valuable resources.

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Apredica offers the following toxicological services:

• Mechanistic Toxicity
• Lysosomal Trapping
• Hemolysis
• Mitochondrial toxicity
• Reactive metabolite assessment
• hERG safety
• Cell Viability (LDH and Neutral red)
• Phototoxicity
• Drug-drug interactions (transporters and cytochrome p450 enzymes)
• Genotoxicity
• GreenScreen HC™
• Ames Test
• In vitro micronucleus test (MNT)
• In vitro Comet
  
• High Content Toxicology
• CellCiphr^® Premier
• CellCiphr^® Hepatotoxicitiy Profiling
• CellCiphr^® Cytotoxicity Profiling
• 3D liver microtissue hepatotoxicity assessment

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References

1. Uetrecht, J. (2008). Idiosyncratic drug reactions: past, present, and future. Chemical Research in Toxicology 21: 84-92.

2. Kaitin, KI. (2008)Obstacles and opportunities in new drug development. Clin Pharmacol Ther. 83(2): 210-2.