Toxicity Testing Services for Drug Discovery

Apredica provides fast turnaround for a wide variety of toxicology research for drug-discovery programs, including both in vitro and in vivo toxicology research. Contact us to learn more our toxicity testing services.

Predictive Toxicology

In recent years tremendous advances have been made in predictive toxicology, allowing early, cost-effective prediction of human toxicity. Identifying compound toxicity as early as possible can better direct your chemistry efforts, and ultimately support improved candidate selection and clinical trial success.

The Safer Medicines Trust has developed a well-done film on this subject. The trailer is below, or see the full film.

Predictive Toxicology Services

Apredica provides a suite of predictive in vitro toxicology services to get the toxicity data you need quickly, accurately, and efficiently. These are available in screening, primary profiling, and full profiling modes.

Apredica offers in vitro cytotoxicity testing of test articles in HepG2, NIH3T3, or HaCaT cells by Neutral Red or MTT assays, as well as High-Content Imaging. We also provide the following specialized toxicity tests, and we routinely develop customized tests for clients' specialized needs. Please inquire about custom cell lines or other in vitro toxicity assays.

• Drug-Drug Interactions
• Genotoxicity
• Hemolysis
• High Content Screening
• hERG Cardiotoxicity
• Mitochondrial Toxicity
• Phospholipidosis
• Phototoxicity
• Reactive Metabolite Toxicity

Toxicology Screening

3 concentrations each unless indicated. Requires 12 compounds or more.

• Mammalian Cytotoxicity HepG2, TK6
• Mitochondrial toxicity
• Phospholipidosis
• hERG (2 concentrations)
• Reactive Metabolites
• 6 major Cyp450 (pooled LC/MS2 concentrations)
• P-gp (CaCO-2 cell functional assay)
• Genotoxicity - GreenScreen HC
• Hemolysis
• Phototoxicity

Primary Toxicology Profile

9 concentrations each unless indicated.

• Mammalian Cytotoxicity HepG2, TK6
• Mitochondrial toxicity
• Phospholipidosis
• hERG (6 conc in duplicate)
• Reactive Metabolites
• Genotoxicity - GreenScreen and GreenScreen + S9

Full Toxicology Profile

9 concentrations each unless indicated.

• Mammalian Cytotoxicity HepG2 & TK6
• Mitochondrial toxicity
• Phospholipidosis
• hERG (6 conc in duplicate)
• Reactive Metabolites
• 5 major Cyp450 (2 concentrations screen + 2 IC50 determinations)
• P-gp (bi-directional + verapamil)
• Genotoxicity - GreenScreen HC + S9
• Hemolysis
• Phototoxicity

In Vivo Preclinical Toxicology

Determining the liabilities and potential for gross toxicity of NCEs early in the preclinical process can save large amounts of time and money on GLP toxicology studies. Apredica offers customized preclinical discovery-phase rodent toxicity studies in both single-escalating and multiple-dosing regiments with rapid turnaround. Please inquire about your preclinical animal tox needs.

Please contact us about these or any cutomized tests that you may need for your drug-discovery program.